Hydrochloric Acid → 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

HRID 562029

反応式

HRID 562029 の反応式
[ClH:1].[NH2:2][C:3]([C:5]1[CH:6]=[C:7]([Br:27])[CH:8]=[C:9]2[C:13]=1[NH:12][CH:11]=[C:10]2[CH:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]1)=[O:4]>O1CCOCC1.CO>[ClH:1].[Br:27][C:7]1[CH:8]=[C:9]2[C:13](=[C:5]([C:3]([NH2:2])=[O:4])[CH:6]=1)[NH:12][CH:11]=[C:10]2[CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59600660tert-butyl 4-(5-bromo-7-carbamoyl-1H-indol-3-yl)piperidine-1-carboxylate

生成物 1

HCID 667232845-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A 4M solution of HCl in dioxane (194 mL) was added to a solution of 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidinecarboxylate (10 g, 23.7 mmol) in methanol (50 mL). The reaction mixture was stirred at room temperature for 4 hours, and the solvent was evaporated under reduced pressure to give the title compound (9.5 g), which was used in the next step without further purification.

後処理

  1. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e3c06bea0b0c42e3b1cc8fcc7ab25cad
出典データセット
uspto-grants-2011_11
特許番号
US08063071B2

関連ノート

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