Ammonia → (Z)-3-amino-N-(3-cyano-4-(dihexylamino)phenyl)but-2-enamide

HRID 56208ノート

反応式

HRID 56208 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([NH:22][C:23](=[O:28])[CH2:24][C:25](=O)[CH3:26])[CH:6]=[CH:7][C:8]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])#[N:2].[NH3:29]>CO>[NH2:29]/[C:25](/[CH3:26])=[CH:24]\[C:23]([NH:22][C:5]1[CH:6]=[CH:7][C:8]([N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:3]([C:1]#[N:2])[CH:4]=1)=[O:28]

参加物

4

反応物 2

HCID 222AmmoniaHCID 90023598N-(3-cyano-4-(dihexylamino)phenyl)-3-oxobutanamide

生成物 1

HCID 90022969(Z)-3-amino-N-(3-cyano-4-(dihexylamino)phenyl)but-2-enamide収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of N-(3-cyano-4-(dihexylamino)phenyl)-3-oxobutanamide (1.47 g, 3.81 mmol), MeOH (15 mL) and ammonia (15 mL) was stirred at rt overnight. The mixture was concentrated in vacuo to give the title compound as black oil (1.30 g, 88%).

後処理

  1. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-af8d51602c5843c0afb91c84da09b43c
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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