2-(5-Bromothiophen-2-yl)piperazine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[4-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate

HRID 562254ノート

反応式

HRID 562254 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:39]([NH2:41])=[O:40])[CH:24]=[C:25]([C:28]4S[C:30]([CH:33]5[CH2:38][NH:37][CH2:36][CH2:35][NH:34]5)=[CH:31][CH:32]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9].Br[C:43]1SC(C2CNCCN2)=C[CH:44]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:14][CH2:15][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:39]([NH2:41])=[O:40])[CH:24]=[C:25]([C:28]4[CH:32]=[CH:31][C:30]([CH:33]5[CH2:38][NH:37][CH2:36][CH2:35][NH:34]5)=[CH:44][CH:43]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:17][CH2:18]1)(=[O:11])=[O:12])[CH3:9]

参加物

3

反応物 2

HCID 197636062-(5-Bromothiophen-2-yl)piperazineHCID 667233023-[1-(ethylsulfonyl)-4-piperidinyl]-5-[5-(2-piperazinyl)-2-thienyl]-1H-indole-7-carboxamide trifluoroacetate

生成物 1

HCID 667229483-[1-(ethylsulfonyl)-4-piperidinyl]-5-[4-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate収率 25.9%

実験手順

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[5-(2-piperazinyl)-2-thienyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 2-(4-bromophenyl)piperazine (94 mg, 0.39 mmol) for 2-(5-bromo-2-thienyl)piperazine to afford 20.5 mg of the title compound (25.9%).

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-25819822f188489b9d71177f0c149c92
出典データセット
uspto-grants-2011_11
特許番号
US08063071B2

反応ノート

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