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HRID 562265作成日：2026年10月26日

(S)-(+)-Tetrahydrofurfurylamine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate

https://huagongshe.com/reaction/562265

反応式

関与物質

役割名称HCID仕込み量
反応物(S)-(+)-TetrahydrofurfurylamineHCID 641530—
反応物3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetateHCID 66723136—
生成物3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetateHCID 6672328034.7%

反応手順

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate, substituting (2S)-3,3-dimethyl-2-butanamine (52 mg, 0.525 mmol) for 1-[(2S)-tetrahydro-2-furanyl]methanamine to afford 19.8 mg of the title compound (34.7%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08063071B2
出典データセットuspto-grants-2011_11
ORD IDord-3cba28d0f3c94995916692448334d866
出典メモuspto-grants-2011_11