Ammonia → (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide
反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([NH:15][C:16](=[O:21])[CH2:17][C:18](=O)[CH3:19])[CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[NH3:24]>CO>[NH2:24]/[C:18](/[CH3:19])=[CH:17]\[C:16]([NH:15][C:5]1[CH:6]=[CH:7][C:8]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:3]([C:2]([F:23])([F:22])[F:1])[CH:4]=1)=[O:21]参加物
4
実験手順
A mixture of N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide (4.0 g, 12.1 mmol), MeOH (20 mL) and ammonia (20 mL) was stirred at rt overnight. The mixture was then concentrated in vacuo to give the title compound, which was used for next step without further purification.
後処理
- concentrationThe mixture was then concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ec3e13da603d435db0061cc3f8e97f5a
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434695B2
反応ノート
読み込み中…