Ammonia → HCID 90030960、化合物
反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[O:6][CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:18](=[O:23])[CH2:19][C:20](=O)[CH3:21])[CH:15]=2)[CH:10]=[CH:9]1)#[N:2].[NH3:27]>CO>[NH2:27]/[C:20](/[CH3:21])=[CH:19]\[C:18]([NH:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][O:6][C:5]2[CH:24]=[CH:25][CH:26]=[C:3]([C:1]#[N:2])[CH:4]=2)=[CH:12][CH:13]=1)=[O:23]参加物
4
実験手順
A mixture of N-(1-((3-cyanophenoxy)methyl)-1H-indol-6-yl)-3-oxobutanamide (1.04 g, 2.99 mmol), MeOH (20 mL) and ammonia (20 mL) was stirred at rt overnight. The mixture was concentrated in vacuo to give the title compound, which was used for next step without further purification.
後処理
- concentrationThe mixture was concentrated in vacuo