Dimethylformamide diethylacetal → Ethyl 3-(dimethylamino)-2-(1H-1,2,3-triazol-1-yl)acrylate
反応式
C(O[CH:4](OCC)[N:5]([CH3:7])[CH3:6])C.[N:11]1([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:15]=[CH:14][N:13]=[N:12]1>>[CH3:4][N:5]([CH3:7])[CH:6]=[C:16]([N:11]1[CH:15]=[CH:14][N:13]=[N:12]1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]参加物
3
反応条件
- 温度
- 100 °C
実験手順
44.2 ml (38.0 g, 257.8 mmol) of N,N-dimethylformamide diethyl acetal are added to 20.0 g (128.9 mmol) of the compound from Example 2A, and the mixture is stirred at 100° C. for 16 h. After cooling to RT, the reaction mixture is concentrated under reduced pressure. The residue is triturated with diethyl ether, filtered off and washed with diethyl ether. Yield: 18.0 g (67% of theory)
後処理
- temperatureAfter cooling to RT
- concentrationthe reaction mixture is concentrated under reduced pressure
- customThe residue is triturated with diethyl ether
- filtrationfiltered off
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-00e041146182450b850d5077fcfcfa55
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067407B2
反応ノート
読み込み中…