Hydrochloric Acid → 2-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine

HRID 562488ノート

反応式

HRID 562488 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][N:5]1[C:13]([O:14]C)=[N:12][C:11]2[C:6]1=[N:7][C:8]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])=[N:9][C:10]=2[NH2:16].Cl>CO.O1CCOCC1>[NH2:16][C:10]1[N:9]=[C:8]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])[N:7]=[C:6]2[C:11]=1[NH:12][C:13](=[O:14])[N:5]2[CH2:4][CH2:3][CH2:2][Br:1]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 231584909-(3-Bromopropyl)-2-butoxy-8-methoxy-9H-purin-6-amine

生成物 1

HCID 592880312-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

The product of step (vi) (35.8 g) was dissolved in methanol (400 ml) and treated with 4M hydrogen chloride in dioxane (100 ml). The mixture was stirred at ambient temperature for 6 hours and concentrated in vacuo. Dichloromethane (500 ml) was added and concentrated in vacuo, which afforded a foam that was taken onto the next step without further purification. Yield 38 g.

後処理

  1. concentrationconcentrated in vacuo
  2. additionDichloromethane (500 ml) was added
  3. concentrationconcentrated in vacuo, which
  4. customafforded a foam that
  5. customwas taken onto the next step without further purification

出典と根拠

ORDレコード
ord-79a2528aeecd488d99ea2f439bd6a450
出典データセット
uspto-grants-2011_11
特許番号
US08067411B2

反応ノート

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