Ammonia → 6-Amino-9-(3-chloropropyl)-2-butoxy-7,9-dihydro-8H-purin-8-one
反応式
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[C:13]([O:14]C)=[N:12][C:11]2[C:6]1=[N:7][C:8]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])=[N:9][C:10]=2[NH2:16].Cl.N>CO.O1CCOCC1>[NH2:16][C:10]1[N:9]=[C:8]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])[N:7]=[C:6]2[C:11]=1[NH:12][C:13](=[O:14])[N:5]2[CH2:4][CH2:3][CH2:2][Cl:1]参加物
6
実験手順
The product of step (i) (29.8 g) was dissolved in methanol (60 ml) and treated with 4M hydrogen chloride in dioxane (60 ml). The mixture was stirred at room temperature for 2 hours, cooled to 0° C. and neutralised with 3.5% aqueous ammonia solution. The solid was filtered off, washed with water then methanol and dried Yield 27.2 g.
後処理
- filtrationThe solid was filtered off
- washwashed with water
- dry with materialmethanol and dried Yield 27.2 g
出典と根拠
- ORDレコード
- ord-08b99920ca224567ab7cc869c9c20f3b
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067411B2
反応ノート
読み込み中…