Ethanol → 4-(3-Fluorophenoxy)butanoic acid

HRID 56251

反応式

HRID 56251 の反応式
[OH-].[K+].O.C(O)C.[F:7][C:8]1[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16]>C(Cl)Cl>[F:7][C:8]1[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

参加物

6

反応物 4

HCID 702EthanolHCID 962WaterHCID 14797Potassium HydroxideHCID 21812847Ethyl 4-(3-fluoro-phenoxy)butanoate

生成物 1

HCID 64860154-(3-Fluorophenoxy)butanoic acid収率 96%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

To a solution of KOH (0.24 g, 4.28 mmol) in mixed solvents of water (3 mL) and ethanol (3 mL) under N2 was added ethyl 4-(3-fluorophenoxy)butanoate (0.30 g, 1.33 mmol) in one portion and the mixture was stirred at 40° C. for 4 h. It was then cooled to rt and 20 mL of DCM was added. The organic layer was washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.25 g, 96%).

後処理

  1. temperatureIt was then cooled to rt
  2. washThe organic layer was washed with brine (20 mL×2)
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fdaf1e14d6bf43bcbc8ae6ddeb79e2ae
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

読み込み中…