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Hydrochloric Acid → n-{[4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]sulfonyl}(phenylamino)carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenylsulphonyl isocyanate | HCID 76096 | — |
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | 4-(1,3-Dioxo-1,3-dihydro-isoindol-2-YL)-benzenesulfonamide | HCID 3586494 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | n-{[4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]sulfonyl}(phenylamino)carboxamide | HCID 22064432 | 100% |
反応手順
To a solution of 4-(1,3-dioxobenzo[c]azolidin-2-yl)benzenesulfonamide in 660 uL of DMSO was added 60 mg (0.40 mmol) of DBU followed by 36 μl (0.33 mmol) of phenylsulfonylisocyanate. After stirring for 0.5 h, the mixture was poured into 1N HCl, cooled, and the precipitate was collected by filtration and dried under vacuum to give 137 mg (100%) of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067428B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-9852f38b1e2945c9aea84b13399fbe52 |
| 出典メモ | uspto-grants-2011_11 |