関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phthaloyl chloride | HCID 6955 | — |
| 反応物 | tert-Butyl (2-aminopyrimidin-5-yl)carbamate | HCID 22064425 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (Tert-butoxy)-n-[2-(1,3-dioxobenzo[c]azolidin-2-yl)pyrimidin-5-yl]carboxamide | HCID 20800274 | 91.1% |
反応手順
To a solution of N-(2-aminopyrimidin-5-yl)(tert-butoxy)carboxamide (0.237 g, 1.0 mmol) in pyridine (1 mL) was added phthaloyl dichloride (0.144 mL, 1.0 mmol). The resulting suspension was stirred at 45° C. for 2 hr, diluted with EtOAc, washed with water and brine, dried and concentrated in vacuo to give crude (tert-butoxy)-N-[2-(1,3-dioxobenzo[c]azolidin-2-yl)pyrimidin-5-yl]carboxamide (0.31 g). ES-MS (M+H)+=341; (M+H-tBu)+=285.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08067428B2 |
|---|
| 出典データセット | uspto-grants-2011_11 |
|---|
| ORD ID | ord-3b0667b4ea38433295acfd38b7f8c48b |
|---|
| 出典メモ | uspto-grants-2011_11 |
|---|
