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3-Acetaminobenzyl alcohol → N-(3-formylphenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Acetaminobenzyl alcohol | HCID 96639 | — |
| 触媒 | Manganese dioxide | HCID 14801 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-(3-formylphenyl)acetamide | HCID 256849 | 93% |
反応手順
A mixture of N-[3-(hydroxymethyl)phenyl]acetamide (10 g, 60.6 mmol) and MnO2 (7.8 g, 90 mmol) in toluene (250 mL) was refluxed for 29 hr, with addition of more MnO2 (0.7 g, 9 mmol) at 24 hr. The reaction was cooled, filtered through Celite and concentrated in vacuo to give N-(3-formylphenyl)acetamide (9.2 g, 75%). ES-MS (M+H)+=164.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067428B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-aeb70fa7a22543d7a8ccc9f5f05cf40f |
| 出典メモ | uspto-grants-2011_11 |