関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Stannous chloride dihydrate | HCID 61436 | — |
| 反応物 | 3-(2-Bromo-4-nitrophenyl)-1,3-dihydroquinazoline-2,4-dione | HCID 22064401 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(4-Amino-2-bromophenyl) 1,3-dihydroquinazoline-2,4-dione | HCID 22064383 | 94% |
反応手順
A suspension of 3-(2-bromo-4-nitrophenyl)-1,3-dihydroquinazoline-2,4-dione (0.18 g, 0.5 mmol) and tin(II) chloride dihydrate (0.45 g, 2.0 mmol) in ethyl acetate (5 mL) was heated at 70° C. for 4 hr. The reaction mixture was then cooled, mixed with Celite, made basic with 4N NaOH (3 mL), filtered through Celite, and concentrated in vacuo to give the desired compound (0.155 g, 94%). ES-MS (M+H)+=332, 334 (Br).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08067428B2 |
|---|
| 出典データセット | uspto-grants-2011_11 |
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| ORD ID | ord-a7655e8ba07c494e8226c31e1e0ce9e3 |
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| 出典メモ | uspto-grants-2011_11 |
|---|
