Nitrogen → 2-(3-Fluorophenoxy)-2-methylpropanoyl chloride

HRID 56276

反応式

HRID 56276 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]([CH3:11])([CH3:10])[C:7](O)=[O:8].[Cl:15]SCl.N#N>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]([CH3:11])([CH3:10])[C:7]([Cl:15])=[O:8]

参加物

4

反応物 3

HCID 947NitrogenHCID 25353Sulfur dichlorideHCID 222707202-(3-fluorophenoxy)-2-methylPropanoic acid

生成物 1

HCID 821138502-(3-Fluorophenoxy)-2-methylpropanoyl chloride

実験手順

To 2-(3-fluorophenoxy)-2-methylpropanoic acid (1.70 g, 8.58 mmol) was added dichlorosulfane (15 mL) dropwise under N2 and the mixture was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound as yellow oil, which was used for next step without further purification.

後処理

  1. temperaturethe mixture was refluxed for 3 h
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-9e3a5970c34243519043534d48bb17a0
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

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