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3-Fluorophenol → 2-(3-Fluorophenoxy)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluorophenol | HCID 9743 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromoacetamide | HCID 69632 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-(3-Fluorophenoxy)acetamide | HCID 18938105 | 30% |
反応手順
A mixture of 3-fluorophenol (11.2 g, 100 mmol), 2-bromoacetamide (13.8 g, 100 mmol), K2CO3 (13.82 g, 100 mmol) and Cs2CO3 (32.58 g, 100 mmol) in acetone (150 mL) was refluxed overnight. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (5.06 g, 30%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434695B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-7eb07fbcc8ef449b86ac184e3c4a8ea6 |
| 出典メモ | uspto-grants-2016_09 |