3-Chlorophenol → 2-(3-Chlorophenoxy)acetamide

HRID 56281

反応式

HRID 56281 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][C:11]([NH2:13])=[O:12].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][CH2:10][C:11]([NH2:13])=[O:12]

参加物

5

反応物 3

HCID 79333-ChlorophenolHCID 11430Potassium CarbonateHCID 696322-Bromoacetamide

生成物 1

HCID 27459692-(3-Chlorophenoxy)acetamide収率 87%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
70 °C

実験手順

A mixture of 3-chlorophenol (2.57 g, 20.0 mmol), 2-bromoacetamide (2.76 g, 20.0 mmol) and K2CO3 (5.53 g, 40.0 mmol) in acetone (40 mL) was stirred at 70° C. overnight. The mixture was then cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (3.22 g, 87%).

後処理

  1. temperatureThe mixture was then cooled to rt
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

出典と根拠

ORDレコード
ord-5678fda726de4720b490e40934cb03aa
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

読み込み中…