Methyl iodide → 2-Bromo-3-nitroanisole

関与物質

役割	名称	HCID	仕込み量
反応物	Methyl iodide	HCID 6328	—
反応物	2-Nitrophenol	HCID 6947	—
反応物	Cesium carbonate	HCID 10796	—
反応物	2-Bromo-3-nitrophenol	HCID 8167254	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	2-Bromo-3-nitroanisole	HCID 17750299	94%

反応手順

The nitrophenol starting material B2 (3.1 g; 14.2 mmol) was dissolved in DMF (20 mL) and to the solution was added ground cesium carbonate (5.58 g; 17.1 mmol) followed by MeI (2.6 mL; 42.5 mmol). The mixture was stirred at room temperature overnight. The DMF was evaporated, the residue taken up in ether (1×200 mL), washed with water (1×200 mL), brine (4×100 mL), dried (MgSO4), filtered and evaporated to afford the crude 2-bromo-3-nitroanisole B3 (94%; 3.1 g) as an orange solid.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08067438B2
出典データセット	uspto-grants-2011_11
ORD ID	ord-62fe4f27dc5a4e17be77b4c04519d7bf
出典メモ	uspto-grants-2011_11