化工社化工社 化学情報印刷レポート · 研究参考用
Cesium fluoride → Methyl 2-(3-cyano-4-fluorophenyl)isonicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium fluoride | HCID 25953 | — |
| 反応物 | Methyl 2-chloropyridine-4-carboxylate | HCID 2736842 | — |
| 反応物 | 3-Cyano-4-fluorophenylboronic acid | HCID 2757964 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | Methyl 2-(3-cyano-4-fluorophenyl)isonicotinate | HCID 66995083 | — |
反応手順
Cesium fluoride and tetrakis(triphenylphosphine)palladium were added to a 1,2-dimethoxyethane solution of (3-cyano-4-fluorophenyl)boronic acid and methyl 2-chloroisonicotinate, and the mixture was heated under reflux under an argon atmosphere to obtain methyl 2-(3-cyano-4-fluorophenyl)isonicotinate. F: 257.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067446B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-8ce8508b2c914983a1090894b2a362d7 |
| 出典メモ | uspto-grants-2011_11 |