関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Fluorophenol | HCID 9743 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl bromodifluoroacetate | HCID 69585 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate | HCID 66455005 | — |
反応手順
A mixture of 3-fluorophenol (2.24 g, 20.0 mmol), ethyl 2-bromo-2,2-difluoroacetate (8.12 g, 40.0 mmol) and K2CO3 (6.91 g, 50.0 mmol) in MeOH (20 mL) was stirred at 70° C. overnight. It was then cooled to rt and filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434695B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-47bd33ea822e493bb4ab17fa47d0f8ef |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
