Dimethylformamide → HCID 18174684、化合物

HRID 563063

反応式

HRID 563063 の反応式
Cl[C:2]1[O:3][C:4]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:6]=1.[C:26]1([C:32]2[N:33]=[CH:34][NH:35][C:36]=2[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[N:6]=[C:2]([N:33]3[C:32]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[C:36]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)[N:35]=[CH:34]3)[O:3][C:4]=2[CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH3:25])=[CH:8][CH:9]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 695884,5-DiphenylimidazoleHCID 10959800HCID 10959800、化合物

生成物 1

HCID 18174684HCID 18174684、化合物収率 46%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2-chloro-4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole (378 mg), 4,5-diphenylimidazole (270 mg), anhydrous potassium carbonate (220 mg) and N,N-dimethylformamide (10 ml) was stirred at 100° C. for 12 hours. The reaction mixture was poured into water, the resulting solid precipitate was filtered and air-dried. Recrystallization of this solid from acetone-isopropyl ether gave 4-(4-chlorophenyl)-2-(4,5-diphenyl-1-imidazolyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole as pale yellow prisms (220 mg, 46%). Melting point 118-119° C.

後処理

  1. filtrationthe resulting solid precipitate was filtered
  2. customair-dried
  3. customRecrystallization of this solid from acetone-isopropyl ether

出典と根拠

ORDレコード
ord-5090f730dd7b4db08ddd882a620d8aeb
出典データセット
uspto-grants-2011_11
特許番号
US08067453B2

関連ノート

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