Hydrochloric Acid → 1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one

HRID 56351

反応式

HRID 56351 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:23])[CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:23])[CH2:9][N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 46901916Tert-butyl 4-[2-(4-fluorophenyl)-2-oxoethyl]piperazine-1-carboxylate

生成物 1

HCID 167690831-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one収率 88.8%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

tert-Butyl 4-(2-(4-fluorophenyl)-2-oxoethyl)piperazine-1-carboxylate (8.65 g, 26.8 mmol), 4 M HCl in dioxane (6 mL) and dioxane (20 mL) were stirred at 43° C. for 1 h. The solvent was removed under reduced pressure and the residue was dried in a vacuum oven to yield the title compound (5.29 g). Exact mass calculated for C12H15FN2O: 222.1. Found: 223.4 (M+H+).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was dried in a vacuum oven

出典と根拠

ORDレコード
ord-7a2fd7d0cc9143d18d10106982b2bccb
出典データセット
uspto-grants-2016_09
特許番号
US09434692B2

関連ノート

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