2-Bromo-5-nitrobenzoic acid → (2-Bromo-5-nitrophenyl)methanol

HRID 563537ノート

反応式

HRID 563537 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].O1CCCC1.B>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[CH2:4][OH:5]

参加物

3

反応物 2

HCID 2430252-Bromo-5-nitrobenzoic acidHCID 2723981Borane;tetrahydrofuran

生成物 1

HCID 18671373(2-Bromo-5-nitrophenyl)methanol

実験手順

To 2-bromo-5-nitrobenzoic acid (5 g, 20 mmol) at 0° C. was added borane tetrahydrofuran complex (1 M in THF; 200 mL, 200 mmol), and the reaction was stirred at room temperature overnight. The mixture was quenched with 1N aqueous HCl to give the title compound.

後処理

  1. customThe mixture was quenched with 1N aqueous HCl

出典と根拠

ORDレコード
ord-10610fa9968e4d3ba8c45c75675bc868
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

反応ノート

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