Ethanol → Ethyl 3-bromo-4-methoxyphenylacetate

HRID 563594ノート

反応式

HRID 563594 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:14][CH2:15]O>S(=O)(=O)(O)O>[CH2:14]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Br:1])[CH:3]=1)[CH3:15]

参加物

4

反応物 2

HCID 702EthanolHCID 1366153-Bromo-4-methoxyphenylacetic acid

生成物 1

HCID 57419861Ethyl 3-bromo-4-methoxyphenylacetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 3-bromo-4-methoxyphenylacetic acid (3.0 g, 12.2 mmol) in EtOH and sulfuric acid was stirred at 100° C. for 2 hours. The mixture was concentrated and partitioned between EtOAc and H2O, and the organic layer was separated to give the title compound.

後処理

  1. concentrationThe mixture was concentrated
  2. custompartitioned between EtOAc and H2O
  3. customthe organic layer was separated

出典と根拠

ORDレコード
ord-e3d6e9063a61482c9b1a0e69f21c57b7
出典データセット
uspto-grants-2011_11
特許番号
US08067445B2

反応ノート

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