Hydrochloric Acid → Methyl 2-(3-bromo-5-chlorophenyl)acetate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.[CH3:14]O>>[CH3:14][O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Br:1])[CH:3]=1参加物
4
反応条件
- 温度
- 90 °C
実験手順
To a solution of (3-bromo-5-chloro-phenyl)-acetic acid (0.400 g, 1.60 mmol) in MeOH (15 mL) was added 4N aqueous HCl (2 mL), and the reaction was stirred at 90° C. for 2 hours. The mixture was concentrated and purified by silica gel chromatography (0-5% EtOAc in hexanes) to give the title compound.
後処理
- concentrationThe mixture was concentrated
- custompurified by silica gel chromatography (0-5% EtOAc in hexanes)
出典と根拠
- ORDレコード
- ord-6ba449ca65fa4d0b898fd51d4f3499cd
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08067445B2
反応ノート
読み込み中…