1-Methyl-4-piperidone → HCID 1476965、化合物

HRID 563862ノート

反応式

HRID 563862 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH:14]=[C:4]1[C:5](=[O:8])[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)[CH3:13]

参加物

4

反応物 2

HCID 740491-Methyl-4-piperidoneHCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 1476965HCID 1476965、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 1-methylpiperidin-4-one (10 g, 88 mmol) in toluene (100 mL) was added 1,1-dimethoxy-N,N-dimethylmethanamine (52.7 g, 0.442 mol). The solution was heated to reflux overnight. The solvents were evaporated in vacuo, heptane (100 ml) was added and the solvents evaporated again to give the desired product. NMR indicated that the product was 70-80% pure and it was used in the next step without further purification.

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvents were evaporated in vacuo, heptane (100 ml)
  4. additionwas added
  5. customthe solvents evaporated again

出典と根拠

ORDレコード
ord-25d2b5b044744d21b224d9b5faf8bfe5
出典データセット
uspto-grants-2011_11
特許番号
US08067589B2

反応ノート

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