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Diisopropylamine → 2-(3-(Di(propan-2-yl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | 3,4-Dihydro-2-hydroxy-4-phenyl-2H-1-benzopyran-6-methanol | HCID 54761596 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(3-(Di(propan-2-yl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenol | HCID 9927971 | — |
反応手順
(2-Hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl)methanol (Example 13, 830 g, 3.24 mol, 1.0 eq) was stirred in methanol (4150 mL, 5.0 mL/g). Diisopropylamine (1362 mL, 9.72 mol, 3.0 eq) was then added over 15 minutes via dropping funnel. The resulting solution was then stirred for one hour under nitrogen.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08067594B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-3e8a149aa00f423f98cf6e4e37a05860 |
| 出典メモ | uspto-grants-2011_11 |