Chlorosuccinimide → 2-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamide

HRID 563888ノート

反応式

HRID 563888 の反応式
[CH3:1][S:2][CH2:3][C:4]([NH:6][C:7]([CH3:12])([C:9]#[C:10][CH3:11])[CH3:8])=[O:5].[Cl:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:13][CH:3]([S:2][CH3:1])[C:4]([NH:6][C:7]([CH3:12])([C:9]#[C:10][CH3:11])[CH3:8])=[O:5]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 860149882-(methylthio)-N-(2-methylpent-3-yn-2-yl)acetamide

生成物 1

HCID 866108822-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamide収率 143.3%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
0 °C

実験手順

The product of Step 1 (0.824 g) was dissolved in carbon tetrachloride (15 ml) with warming. The solution was then cooled to 0° C. and N-chlorosuccinimide (NCS, 0.653 g) was then gradually added and the mixture was stirred at ambient temperature for 2 hours. The reaction mixture was filtered to remove succinimide and the resulting liquid was evaporated to give 2-(chloro)-2-(methylthio)-N-(2-methylpent-3-yn-2-yl) acetamide as a clear oil (1.4 g), which was used without further purification.

後処理

  1. temperaturewith warming
  2. filtrationThe reaction mixture was filtered
  3. customto remove succinimide
  4. customthe resulting liquid was evaporated

出典と根拠

ORDレコード
ord-3e105cff6cdb43a3a46d8d5a2a7bebfa
出典データセット
uspto-grants-2011_11
特許番号
US08067592B2

反応ノート

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