1-[4-(1-Hydroxyethyl)phenyl]ethan-1-one → 2-Bromo-1-[4-(1-hydroxy-ethyl)-phenyl]ethanone

反応式

C(OC(N1CCC2C(=CC=C(C(=O)C[Br:20])C=2)C1)=O)(C)(C)C.[OH:22][CH:23]([C:25]1[CH:30]=[CH:29][C:28]([C:31](=[O:33])[CH3:32])=[CH:27][CH:26]=1)[CH3:24]>>[Br:20][CH2:32][C:31]([C:28]1[CH:29]=[CH:30][C:25]([CH:23]([OH:22])[CH3:24])=[CH:26][CH:27]=1)=[O:33]

参加物

反応物 2

HCID 125880941-[4-(1-Hydroxyethyl)phenyl]ethan-1-one

HCID 866236896-(2-Bromo-acetyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic Acid Tert-Butyl Ester

生成物 1

HCID 866236902-Bromo-1-[4-(1-hydroxy-ethyl)-phenyl]ethanone

実験手順

2-Bromo-1-[4-(1-hydroxy-ethyl)-phenyl]-ethanone is prepared following preparation 29c from 600 mg (3.65 mmol) 1-[4-(1-hydroxy-ethyl)-phenyl]-ethanone.

出典と根拠

ORDレコード: ord-c52dae18a2284af08d03db7cf9bbfd78
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08067590B2

反応ノート

読み込み中…