(2-Amino-5-bromo-3-chlorophenyl)methanol → 2-Amino-5-bromo-3-chlorobenzaldehyde

HRID 56449

反応式

HRID 56449 の反応式
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

参加物

4

反応物 1

HCID 67080684(2-Amino-5-bromo-3-chlorophenyl)methanol

生成物 1

HCID 916663072-Amino-5-bromo-3-chlorobenzaldehyde収率 91%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (2-amino-5-bromo-3-chlorophenyl)methanol (10.0 g, 42.5 mmol) and manganese oxide (21.9 g, 255 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (9.0 g, 91%), which was directly used in the next step without further purification.

後処理

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-7e7701d9d0d548799f1f2084c43bcec7
出典データセット
uspto-grants-2016_09
特許番号
US09434700B2

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