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(2-Amino-5-bromo-4-chlorophenyl)methanol → 2-Amino-5-bromo-4-chlorobenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Amino-5-bromo-4-chlorophenyl)methanol | HCID 67081018 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Amino-5-bromo-4-chlorobenzaldehyde | HCID 89419680 | 83.6% |
反応手順
A mixture of (2-amino-5-bromo-4-chlorophenyl)methanol (6 g, 25.5 mmol) and manganese(IV) oxide (15.5 g, 0.178 mol) in dichloromethane (100 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (5 g, 81%). MS (ES+) C7H5BrClNO requires: 233, 235, found: 234, 236 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434700B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-6c416bf047144bc99092021fcac746e0 |
| 出典メモ | uspto-grants-2016_09 |