Urea → HCID 178517413、化合物

HRID 56456

反応式

HRID 56456 の反応式
[NH2:1][C:2]1[CH:9]=[C:8]([Cl:10])[C:7]([Br:11])=[CH:6][C:3]=1[CH:4]=O.[NH2:12][C:13](N)=[O:14]>>[Br:11][C:7]1[CH:6]=[C:3]2[C:2](=[CH:9][C:8]=1[Cl:10])[N:1]=[C:13]([OH:14])[N:12]=[CH:4]2

参加物

3

反応物 2

HCID 1176UreaHCID 894196802-Amino-5-bromo-4-chlorobenzaldehyde

生成物 1

HCID 178517413HCID 178517413、化合物

反応条件

温度
180 °C

実験手順

A mixture of 2-amino-5-bromo-4-chlorobenzaldehyde (5 g, 21.46 mmol) and urea (18 g, 300.0 mmol) was stirred at 180° C. for 5 hours. LCMS monitored the reaction was completed. The mixture was cooled to room temperature, washed with water (100 mL×3) and filtered. The filtration cake was dried to get the title compound as a yellow solid (6 g (crude, 100%). MS (ES+) C8H4BrClN2O requires: 258, 260, found: 259, 261 [M+H]+.

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. washwashed with water (100 mL×3)
  3. filtrationfiltered
  4. customThe filtration cake was dried

出典と根拠

ORDレコード
ord-f79702e4626c493788d23e68740f9c30
出典データセット
uspto-grants-2016_09
特許番号
US09434700B2

関連ノート

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