(2-Amino-5-bromo-3-fluorophenyl)methanol → 2-Amino-5-bromo-3-fluorobenzaldehyde

HRID 56470

反応式

HRID 56470 の反応式
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

参加物

4

反応物 1

HCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

生成物 1

HCID 542514502-Amino-5-bromo-3-fluorobenzaldehyde収率 85%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

後処理

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-004fce44929f4e97a083ea9f5adc78fc
出典データセット
uspto-grants-2016_09
特許番号
US09434700B2

関連ノート

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