4-Amino-5-pyrimidinecarbonitrile → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide

HRID 564733ノート

反応式

HRID 564733 の反応式
[N+](C1C=CC(O[C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=CC=1)([O-])=O.[NH2:26][C:27]1[C:32]([C:33]#[N:34])=[CH:31][N:30]=[CH:29][N:28]=1>>[C:33]([C:32]1[C:27]([NH:26][C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=[N:28][CH:29]=[N:30][CH:31]=1)#[N:34]

参加物

3

反応物 2

HCID 7372084-Amino-5-pyrimidinecarbonitrileHCID 541193452-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester

生成物 1

HCID 443653302-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide収率 58.2%

実験手順

Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (200 mg) and 4-aminopyrimidine-5-carbonitrile (84 mg). Purification by trituration with ethyl acetate and methanol gave the title compound (110 mg) as an off white solid.

後処理

  1. customPurification by trituration with ethyl acetate and methanol

出典と根拠

ORDレコード
ord-1f803e18aa6941ada2a94ee8434d3e23
出典データセット
uspto-grants-2001_01
特許番号
US06169090A

反応ノート

読み込み中…