3-Methoxy-4-aminopyridine → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methoxypyridin-4-yl)amide
反応式
[N+](C1C=CC(O[C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=CC=1)([O-])=O.[NH2:26][C:27]1[CH:32]=[CH:31][N:30]=[CH:29][C:28]=1[O:33][CH3:34]>>[CH3:34][O:33][C:28]1[CH:29]=[N:30][CH:31]=[CH:32][C:27]=1[NH:26][C:11]([C:13]1[C:14]2[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=2[C:16]([O:19][CH3:20])=[N:17][CH:18]=1)=[O:12]参加物
3
実験手順
Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (170 mg) and 4-amino-3-methoxypyridine (120 mg). Purification by column chromatography on silica eluting with ethyl acetate gave the title compound (0.14 g) as an off white solid.
後処理
- customPurification by column chromatography on silica eluting with ethyl acetate