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4-Amino-3,5-dichlorobenzonitrile → 7-Difluoromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-3,5-dichlorobenzonitrile | HCID 522706 | — |
| 反応物 | 7-Difluoromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester | HCID 53891029 | — |
| 生成物 | 7-Difluoromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide | HCID 57114137 | 10.7% |
反応手順
Starting from 7-difluromethoxy-2-ethylfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (100 mg) and 4-amino-3,5-dichlorobenzonitrile (99 mg). Purification by column chromatography on silica eluting with 1% methanol in dichloromethane afforded the title compound as a white solid (12 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06169090A |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-b44cebf235124847987b7aea7b1b76e0 |
| 出典メモ | uspto-grants-2001_01 |