(6-Amino-3-bromo-2-fluorophenyl)methanol → 6-Amino-3-bromo-2-fluorobenzaldehyde
反応式
[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[C:6]([F:10])[C:5]([Br:11])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([F:10])[C:5]([Br:11])=[CH:4][CH:3]=1参加物
4
実験手順
A suspension mixture of (6-amino-3-bromo-2-fluorophenyl)methanol (8.3 g, 37.72 mmol) and manganese(IV) oxide (19.68 g, 226.32 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title product as a light yellow solid (6.0 g, 73%), which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO requires: 217, found: 218, 220 [M+H]+.
後処理
- filtrationThe solid was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-155644f5eff84fe2bb149bba65187648
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434700B2
反応ノート
読み込み中…