2-(Methylamino)ethanol → 6-[N-Methyl-N-(2-hydroxyethyl)amino]-4-(4-phenylsulphonylanilino)pyrido[3,4-d]pyrimidine
反応式
Cl[C:2]1[N:27]=[CH:26][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([S:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)(=[O:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH3:28][NH:29][CH2:30][CH2:31][OH:32]>>[CH3:28][N:29]([C:2]1[N:27]=[CH:26][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([S:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)(=[O:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1)[CH2:30][CH2:31][OH:32]参加物
3
実験手順
Prepared according to Procedure C from 6-chloro4-(4-phenylsulphonylanilino)-pyrido[3,4-d]pyrimidine and 2-(methylamino)ethanol; δH [2H6]-DMSO 9.99 (1H,s), 8.89 (1H,s), 8.48 (1H,s), 8.20 (2H,d), 7.97-8.09 (4H,m), 7.60-7.78 (3H,m), 7.27 (1H,s), 4.27 (1H,t), 3.75-3.85 (2H,m), 3.60-3.71 (2H,m), 3.21 (3H,s); m/z (M+1)+436.
後処理
- customPrepared