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Ammonia → 4-(3-Fluoro-benzyloxy)-phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | 3-Fluorobenzyl bromide | HCID 68007 | — |
| 反応物 | 4-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine | HCID 22727453 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(3-Fluoro-benzyloxy)-phenylamine | HCID 16775314 | — |
反応手順
4-(3-Fluorobenzyloxy)aniline was prepared from 4-nitrophenol (Aldrich) and 3-fluorobenzylbromide (Aldrich) according to Procedure D. This was reacted with 4-chloro-6-(N,N-dimethylamino)pyrido[3,4-d]pyrimidine according to Procedure A to give the product; tic (dichloromethane:ethanol:aq.ammonia, 100:8:1) Rf 0.48; m/z (M+1 )+390.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06169091A |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-2a968be830164788a87af789fdf0c990 |
| 出典メモ | uspto-grants-2001_01 |