Triethylamine → 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline

HRID 564811ノート

反応式

HRID 564811 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=1)=[O:23]>C(Cl)Cl>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH:11][C:22]([O:24][C:25]3[CH:26]=[CH:27][C:28]([N+:31]([O-:33])=[O:32])=[CH:29][CH:30]=3)=[O:23])=[CH:9][CH:8]=2)[CH2:5][CH2:6]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 821294-Nitrophenyl chloroformate

生成物 1

HCID 227075274-morpholino-N-(4-nitrophenoxycarbonyl)aniline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2.60 g (14.6 mmol) of 4-morpholinoaniline in 20 ml of methylene chloride were added 14.07 ml (105 mmol) of triethylamine and 3.53 g (17.5 mmol) of 4-nitrophenyl chloroformate under ice-cooling, followed by stirring at room temperature for 7 hours. After the solvent was evaporated, water was added to the residue, and the precipitated crystals were collected by filtration, washed water, and dried to give 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline.

後処理

  1. temperaturecooling
  2. customAfter the solvent was evaporated
  3. additionwater was added to the residue
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed water
  6. customdried

出典と根拠

ORDレコード
ord-0b0958d5bf844fca996bcb494cb7e5e9
出典データセット
uspto-grants-2001_01
特許番号
US06169088A

反応ノート

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