HCID 22113417、化合物 → 2(1H)-Pyridinone,6-(difluoromethyl)-(9CI)
反応式
C([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]([F:14])[F:13])[N:7]=1)(C)(C)C>ClCCl>[F:13][CH:12]([F:14])[C:8]1[NH:7][C:6](=[O:5])[CH:11]=[CH:10][CH:9]=1参加物
3
実験手順
To a solution of 2-tert-butoxy-6-difluoromethylpyridine (4.3 g) in dichloromethane (25 ml) trifluoroacetic acid (2 ml) was added. The reaction was stirred for 16 hours and then concentrated. The residue was diluted with water and neutralised with sodium bicarbonate. The solid formed was extracted into ethyl acetate, dried and concentrated to give 6-difluoromethylpyrid-2-one (3.2 g, 72% yield) as a white solid; 1H NMR (270 MHz): δ 6.31, 6.53, 6.75 (1H,t), 6.56(1H,m), 6.75(1H,m), 7.52(1H,m), 12.5(1H,brs) ppm.
後処理
- concentrationconcentrated
- additionThe residue was diluted with water and neutralised with sodium bicarbonate
- customThe solid formed
- extractionwas extracted into ethyl acetate
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2b22c98a82484b76bd814c4828eb6f7c
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06169101A
反応ノート
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