Methylamine → 5-[(5-chloro-1H-indol-3-yl)methyl]-2-(methylamino)-1,3-oxazol-4-one
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH:12]1[O:16][C:15]([N:17](C)[CH3:18])=[N:14][C:13]1=[O:20].CN>CCOCC>[CH3:18][NH:17][C:15]1[O:16][CH:12]([CH2:11][C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=3)[NH:7][CH:6]=2)[C:13](=[O:20])[N:14]=1参加物
4
反応条件
- 温度
- -6 °C
実験手順
To [(5-chloroindol-3-yl)methyl]-2-dimethylamino-2-oxazolin-4-one (200 mg) was added methylamine (20 ml). The mixture was refluxed at −6° C. for 1 hour. Removal of methylamine gave a residue, to which was added ether. The titled compound (120 mg) was obtained as a crystal.
後処理
- customRemoval of methylamine
- customgave a residue
出典と根拠
- ORDレコード
- ord-d38cdaa381834c4c91c5a1cc3bcf25c6
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06169102A
反応ノート
読み込み中…