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Sodium Hydroxide → Methyl 1-[2-(2-tetrahydropyranyl)oxyethyl]-2-indolecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 1H-indole-2-carboxylate | HCID 70992 | — |
| 反応物 | 2H-Pyran, tetrahydro-2-(2-iodoethoxy)- | HCID 11118662 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 1-[2-(2-tetrahydropyranyl)oxyethyl]-2-indolecarboxylate | HCID 21194121 | 83% |
反応手順
The reaction was carried out in a manner similar to Reference Example 5 except for using 2.0 g (11.4 mmol) of methyl 2-indolecarboxylate, 0.55 g (13.7 mmol) of 60% sodium hydroxide, 3.63 g (13.7 mmol) of 2-(2-iodo-ethoxy)tetrahydropyran (prepared from 2-iodoethanol and 3,4-dihydro-2H-pyran) and 50 ml of dimethylformamide. Thus, 2.87 g (83.0%) of methyl 1-[2-(2-tetrahydro-pyranyl)oxyethyl]-2-indolecarboxylate was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06169107A |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-2308de2065344a15ab677c375e99d3da |
| 出典メモ | uspto-grants-2001_01 |