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Sodium Hydroxide → methyl 1-(3-tert-butoxycarbonylaminopropyl)-1H-indole-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 1H-indole-2-carboxylate | HCID 70992 | — |
| 反応物 | tert-butyl N-(3-iodopropyl)carbamate | HCID 11231463 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | methyl 1-(3-tert-butoxycarbonylaminopropyl)-1H-indole-2-carboxylate | HCID 10830411 | 27% |
反応手順
The reaction was carried out in a manner similar to Reference Example 5 except for using 5.00 g (28.5 mmol) of methyl 2-indolecarboxylate, 1.26 g (31.4 mmol) of 60% sodium hydroxide, 12.3 g (43.2 mmol) of tert-butyl N-(3-iodopropyl)carbamate (prepared from 3-iodopropyl-amine and di-tert-butyl dicarbonate) and 60 ml of dimethylformamide. Thus, 2.54 g (27%) of methyl 1-(3-tert-butoxycarbonylaminopropyl)-2-indolecarboxylate was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06169107A |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-0897eb3eed3143c18f23b3bf0bddb633 |
| 出典メモ | uspto-grants-2001_01 |