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Acridine Orange Base → 10-N(10-Hydroxy-1-decyl)-3,6 bis(dimethylamino)acridine bromide salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acridine Orange Base | HCID 62344 | — |
| 反応物 | 1-Decanol, 10-bromo- | HCID 104507 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 10-N(10-Hydroxy-1-decyl)-3,6 bis(dimethylamino)acridine bromide salt | HCID 86753341 | — |
反応手順
3,6-bis(dimethylamino)acridine (1.0 millimole) is dissolved in DMF (100 mL) containing 1.1 equivalent of tertiary amine base. To this is added 10-hydroxy-1-bromo decane (1.1 millimole), and the mixture is heated to reflux. When monitoring by TLC shows no remaining 3,6-bis(dimethylamino)acridine, the reaction is cooled and the 10-N-(10-hydroxy-1-decyl)-3,6-bis(dimethylamino)acridine is isolated (0.75 millimoles).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06171859B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-f6ff3aea167649f4b9996cc75b799635 |
| 出典メモ | uspto-grants-2001_01 |