Ethanol → Ethyl 2-(2-chloroethoxy)acetate

HRID 565182

反応式

HRID 565182 の反応式
[Cl:1][CH2:2][CH2:3][O:4][CH2:5][C:6]([OH:8])=[O:7].OS(O)(=O)=O.[CH2:14](O)[CH3:15]>>[CH2:14]([O:7][C:6](=[O:8])[CH2:5][O:4][CH2:3][CH2:2][Cl:1])[CH3:15]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 109205842-(2-Chloroethoxy)acetic acid

生成物 1

HCID 10964894Ethyl 2-(2-chloroethoxy)acetate収率 89%

実験手順

54.1 g (390 mmol) M24 obtained from the preceding reaction step was dissolved in 380 ml absolute ethanol and 9 ml conc. H2SO4 was added. The mixture was heated at reflux for 18 hours. Most of the ethanol was evaporated and the residue was dissolved in 400 ml CHCl3/100 ml water and basified with powder NaHCO3. The organic phase was washed with 2×400 ml saturated NaHCO3 and dried over Na2SO4. The solvent was evaporated to afford 58.3 g clear oil (yield: 89%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 18 hours
  3. customMost of the ethanol was evaporated
  4. dissolutionthe residue was dissolved in 400 ml CHCl3/100 ml water and basified with powder NaHCO3
  5. washThe organic phase was washed with 2×400 ml saturated NaHCO3
  6. dry with materialdried over Na2SO4
  7. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-05a4b7d3991b4ddcb9ef706af3926760
出典データセット
uspto-grants-2001_01
特許番号
US06171866B2

関連ノート

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