2,4-Difluorobenzaldehyde → HCID 54311230、化合物

HRID 565217ノート

反応式

HRID 565217 の反応式
[C:1]([CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])(=[O:4])[CH2:2][CH3:3].[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH:19]=O>C1C=CC=CC=1.C([O-])(=O)C.[NH2+]1CCCCC1>[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH:19]=[C:5]([C:1](=[O:4])[CH2:2][CH3:3])[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7]

参加物

5

反応物 2

HCID 737702,4-DifluorobenzaldehydeHCID 12425357HCID 12425357、化合物

生成物 1

HCID 54311230HCID 54311230、化合物収率 100.3%

試薬・触媒・溶媒 2

HCID 3014295Piperidinium acetate触媒HCID 241Benzene溶媒

実験手順

A solution of benzyl propionylacetate (157 g, 0.758 mol), 2,4-difluorobenzaldehyde (107.65 g, 0.758 mol), and piperidinium acetate (5.49 g, 38 mmol) in benzene (1 L) were stirred at room temperature for 96 h. The mixture was washed with water (2×100 mL), dried (magnesium sulfate) and the solvent evaporated under reduced pressure to yield the product as a pale yellow syrup (251.2 g) which was used in the next step without further purification.

後処理

  1. washThe mixture was washed with water (2×100 mL)
  2. dry with materialdried (magnesium sulfate)
  3. customthe solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e6e121c901fb40bc93d2b5e9f258c83b
出典データセット
uspto-grants-2001_01
特許番号
US06172066B2

反応ノート

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