Bromine → 2-Bromo-1-(2,5-difluorophenyl)propan-1-one
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:13]Br>C(OCC)C>[Br:13][CH:10]([CH3:11])[C:9]([C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])=[O:12]参加物
4
実験手順
To a solution of 2′,5′-difluoropropiophenone (2.12 g) in diethyl ether (20 ml) under ice-cooling was added bromine dropwise, and the mixture was stirred at room temperature overnight. To this reaction mixture was added ice and the diethyl ether layer was separated, followed by washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order and dried over anhydrous magnesium sulfate (MgSO4). The ether layer was concentrated under reduced pressure to provide the title compound.
後処理
- additionTo this reaction mixture was added ice
- customthe diethyl ether layer was separated
- washby washing with water and saturated aqueous solution of sodium hydrogen carbonate in that order
- dry with materialdried over anhydrous magnesium sulfate (MgSO4)
- concentrationThe ether layer was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-d814b0b583cd4e30968c3e9452de0694
- 出典データセット
- uspto-grants-2001_01
- 特許番号
- US06172102B2
反応ノート
読み込み中…