1,1-Dicyano-2-phenyl-2-(1-bromoethyl)ethylene → HCID 22111312、化合物

反応式

[NH2:1][C:2]1[NH:3][C:4]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8].C(C(C#N)=C(C1C=CC=CC=1)C(Br)C)#N.[ClH:31].CO>CO>[ClH:31].[NH2:1][C:2]1[NH:3][C:4]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8]

参加物

実験手順

2-Amino-3-cyano-4-methyl-5-(3-pyridyl)pyrrole (compound No. 8) obtained in the same manner as Example 1 (5.0 g) was dissolved in methanol (220 ml) under heating, followed by addition of 40% HCl-methanol (4 ml) under ice-cooling with stirring. The separated crystals were collected by filtration, washed with methanol (50 ml) twice and diethyl ether (50 ml) 3 times, and air-dried. The crude crystals thus obtained were recrystallized from methanol to provide the title compound as reddish brown crystals (3.4 g). m.p. 279-281° C.