化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → (2S)-(-)-1-(4-indolyloxy)-3-(4-(2,6-dimethylphenyl)piperazin-1-yl)-2-propanol ethanedioate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Oxalic Acid | HCID 971 | — |
| 反応物 | 1-(2,6-Xylyl)piperazine | HCID 70538 | — |
| 反応物 | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (2S)-(-)-1-(4-indolyloxy)-3-(4-(2,6-dimethylphenyl)piperazin-1-yl)-2-propanol ethanedioate | HCID 131719666 | — |
反応手順
The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 1-(2,6-dimethylphenyl)piperazine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 50% overall yield. FDMS m/e=379 (M+ of free base). α[D]589=−11.89 (c=0.47, methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06172073B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-3ca898fdfac44b9b932837efca74705d |
| 出典メモ | uspto-grants-2001_01 |